产品属性:
产品名称
规格
CAS号
型号
Clopidogrel Carboxylic Acid (hydrochloride)
10mg 5mg 500μg 1mg
144750-42-5
EY-Y0164858
Cas No.144750-42-5
别名 N/A
化学名 N/A
分子式 C15H14ClNO2S ?HCl
分子量 344.3
溶解度 DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request 产品描述: Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity. An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite. Clopidogrel carboxylic acid is a major inactive metabolite of clopidogrel. Most (85%) of circulating clopidogrel is hydrolyzed by esterases to this carboxylic acid form. This inactive metabolite can be used as a reference standard for quantitative analysis of clopidogrel metabolism.
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