产品属性:
产品名称
规格
CAS号
型号
JHU-083
1mg 5mg 10mg
1998725-11-3
EY-Y0164915
Cas No.1998725-11-3
别名 N/A
化学名 N/A
分子式 C14H24N4O4
分子量 312.36
溶解度 DMSO: 100 mg/mL (320.14 mM)
储存条件 Store at -20°C, protect from light, stored under nitrogen General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request 产品描述: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells[1]. Blocking the function of glutaminase by the glutamine antagonist JHU-083 in experimental cerebral malaria (ECM) can result in a net decrease of glutamate levels in the animals[2]. Glutamine[2]
[1]. Zhu X, et al. JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress. Neuropsychopharmacology. 2019 Mar;44(4):683-694. [2]. Riggle BA, et al. MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12024-E12033.
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