产品属性:
产品名称 | 规格 | CAS号 | 型号 |
GC376 (sodium salt) | 25mg 50mg 100mg 250mg | 1416992-39-6 | EY-Y0164941 |
Cas No.1416992-39-6
别名 N/A
化学名 N/A
分子式 C21H30N3O8S?Na
分子量 507.5
溶解度 DMF: 10 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件 Store at-20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述:
GC376 is an inhibitor of 3C- and 3C-like proteases.1 It inhibits recombinant poliovirus, foot and mouth disease virus (FMDV), and human rhinovirus (HRV) 3C proteases (IC50s = 1.77, 1.16, and 0.2 μM, respectively). GC376 also inhibits recombinant Norwalk virus, MD145 virus, transmissible gastroenteritis virus (TGEV), and severe acute respiratory syndrome coronavirus (SARS-CoV) 3C-like proteases (IC50s = 0.49, 0.96, 0.82 and 4.35 μM, respectively). It reduces the cytopathic effect of SARS-CoV-2 in infected Vero E6 cells (EC50 = 3.37 μM).2 GC376 also reduces liver viral titers by 9.86- and 21.99-fold in a model of murine hepatitis virus (MHV A59) infection when administered at doses of 50 and 100 mg/kg per day, respectively.3
1.Kim, Y., Lovell, S., Tiew, K.-C., et al.Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronavirusesJ. Virol.86(21)11754-11762(2012) 2.Ma, C., Sacco, M.D., Hurst, B., et al.Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main proteaseCell Res.30(8)678-692(2020) 3.Kim, Y., Shivanna, V., Narayanan, S., et al.Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline calicivirusesJ. Virol.89(9)4942-4950(2015)
关键字: 1416992-39-6;C21H30N3O8S?Na;GC376 (sodium salt);
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业,公司自成立以来,秉承""全心全意服务于科研工作者""的企业理念,立足生物科技领域,运用生物技术和科研试剂,发展现代生物科技,为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品,服务生物科技领域的科学研究人员。
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