产品属性:
产品名称
规格
CAS号
型号
ATH686
10mM*1 mL in DMSO 5 mg 10 mg 25 mg 50 mg
853299-52-2
EY-Y0165200
Cas No.853299-52-2
别名 N/A
化学名 N/A
分子式 C25H28F3N7O2
分子量 515.53
溶解度 DMSO : 250 mg/mL (484.94 mM; Need ultrasonic)
储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request 产品描述: ATH686 (1-100 µM; 3 days) potently inhibits cell proliferation (IC50 around 0.001 µM) via induction of apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells[1]. ATH686 (10 nM; for 15 minutes) inhibits autophosphorylation of mutant FLT3 in FLT3-ITD-Ba/F3 cells[1].
[1]. Ellen Weisberg, et al. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 Oct;1(10):1021-32.
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