产品属性:
产品名称
规格
CAS号
型号
EC359
10mM*1mL in DMSO 5mg 10mg 50mg 100mg 200mg 500mg
2012591-09-0
EY-Y0165378
Cas No.2012591-09-0
别名 N/A
化学名 N/A
分子式 C36H38F2O2
分子量 540.68
溶解度 DMSO: 125 mg/mL (231.19 mM)
储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request 产品描述: EC359 is a potent, selective, high affinity and orally active leukemia inhibitory factor receptor (LIFR) inhibitor with a Kd of 10.2 nM, which directly interacts with LIFR to effectively block LIF/LIFR interactions[1].
[1]. Viswanadhapalli S, et al. EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer. Mol Cancer Ther. 2019 Aug;18(8):1341-1354.
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