产品属性:
产品名称
规格
CAS号
型号
CAY10625
1mg 5mg 10mg
137346-42-0
EY-Y0165625
Cas No.137346-42-0
别名 N/A
化学名 N/A
分子式 C25H26N4O4
分子量 446.5
溶解度 DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 0.5 mg/ml
储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request 产品描述: Survivin is a cellular protein implicated in cell survival by interacting with and inhibiting the apoptotic function of several proteins including Smac/DIABLO, caspase-3, and caspase-7. Survivin also plays a role in the regulation of the cell cycle as part of a protein complex that includes INCENP, Aurora B kinase, and Borealin. CAY10625 is an antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/DIABLO, exhibiting an IC50 value of 2.2 μM. It inhibits the interaction of survivin with INCENP less effectively with an IC50 value of 20 μM. CAY10625 is cell-permeable and sensitizes cells to the induction of apoptosis by doxorubicin.
上海一研生物科技有限公司
联系商家时请提及chemicalbook,有助于交易顺利完成!
上海一研