一般描述
3-(Benzylamino)propionitrile undergoes aza-type Michael reaction with 1-hydroxymethyl-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester under mild conditions.
应用
3-(Benzylamino)propionitrile was used as starting reagent in the synthesis of:(3R,4S)-1-benzyl-4-phenylpyrrolidine-3-carboxylic acid, key chiral building block for synthesis of biologically active compounds1-{[benzyl-(2-cyano-ethyl)-amino]-methyl}-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester3-[benzyl-(3,5-dimethyl-pyrazol-1-ylmethyl)-amino]-propionitrile
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
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