Product Name:CRSP-1
CAS No.:697327-12-1
Synonyms:CT受体激动剂多肽
Catalog No.:120P29
Brand:HongTide(上海鸿肽生物)
Description:CRSP-1是一种内源性中枢降钙素(CT)受体激动剂多肽,序列中含有38个氨基酸,包含一对二硫键结构,其刺激cAMP形成的效力是CT的350倍(ED50值分别为0.2和71nM)。对降钙素基因相关肽(CGRP)和肾上腺髓质素受体无活性。抑制多核破骨细胞的形成,在体外具有与CT相似的功效。 抑制自由进食大鼠的食物摄入并提高体温,并显着降低体内血浆钙水平。
CRSP-1 is an endogenous central calcitonin (CT) receptor agonist peptide. The sequence contains 38 amino acids and a pair of disulfide bonds. Its effect of stimulating the formation of cAMP is 350 times that of CT (ED50 values are 0.2 and 71 nM respectively). It has no activity on calcitonin gene-related peptide (CGRP) and adrenomedullin receptor. It inhibits the formation of multinucleated osteoclasts and has the same effect as CT in vitro. Inhibit the food intake and increase the body temperature of free-eating rats, and significantly reduce the plasma calcium level in vivo.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | SCNTATCMTHRLVGLLSRSGSMVRSNLLPTKMGFKVFG-NH2(Disulfide bridge:Cys2-Cys7) |
Sequence(3-letter code) | H-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Met-Thr-His-Arg-Leu-Val-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Ser-Met-Val-Arg-Ser- Asn-Leu-Leu-Pro-Thr-Lys-Met-Gly-Phe-Lys-Val-Phe-Gly-NH2(Disulfide bridge:Cys2-Cys7) |
Peptide Structure |
|
Molecular Formula | C175H294N54O49S5 |
Molecular Weight | 4098.91 |
订购联系方式:
上海鸿肽生物科技有限公司
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QQ: 3259098395
邮箱:sales1@hongtide.com
关键字: 697327-12-1;CT受体激动剂多肽;CRSP-1;多肽;多肽合成;
上海鸿肽生物科技有限公司(简称:鸿肽生物)是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖:定制多肽、目录多肽、氨基酸衍生物、小分子化合物;公司自成立以来,秉持“用质量作船, 以服务为帆,为科研服务”的企业理念,为国内外众多科研工作者提供了优质的服务及产品。