Product Name：vosoritide
CAS No.：1480724-61-5
Synonyms：Vosoritide acetate；伏索利肽
Catalog No.：218P043
Brand：HongTide（上海鸿肽）
Description：伏索利肽是由39个氨基酸组成的环状多肽，通过与一种称为纳尿肽受体B型（NPR-B）的受体（目标）结合而起作用，该受体可减少成纤维细胞生长因子受体3（FGFR3）的活性。FGFR3是一种受体，通常由一种称为酸性和基本成纤维细胞生长因子的蛋白质激活时，对软骨和骨骼生长进行调节。伏索利肽通过抑制软骨细胞的发育（细胞增殖和分化）来达到这一作用，软骨细胞是产生和维持软骨基质的细胞，这也是骨骼生长所必需的。患有腺细胞增多症的儿童有几种可能的FGFR3突变之一，导致这种受体的构成（永久）活性，导致软骨细胞活动整体减少，从而骨骼生长。
Vosolide is a cyclic peptide composed of 39 amino acids that acts by binding to a receptor (target) called the Natriuretic Peptide Receptor Type B (NPR-B), which reduces the activity of fibroblast growth factor receptor 3 (FGFR3). FGFR3 is a receptor that regulates cartilage and bone growth when activated by a protein called acidic and basic fibroblast growth factor. Vosolide achieves this effect by inhibiting the development (cell proliferation and differentiation) of chondrocytes, the cells that produce and maintain cartilage matrix, which is also necessary for bone growth. Children with adenocytosis have one of several possible mutations in FGFR3, leading to the constitutive (permanent) activity of this receptor, resulting in an overall decrease in chondrocyte activity, leading to bone growth.
Purity (HPLC) ≥95.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | PGQEHPNARKYKGANKKGLSKGCFGLKLDRIGSMSGLGC(Disulfide bridge:Cys23-Cys39) |
Sequence(3-letter code) | H-Pro-Gly-Gln-Glu-His-Pro-Asn-Ala-Arg-Lys-Tyr-Lys-Gly-Ala-Asn-Lys-Lys-Gly-Leu-Ser-Lys-Gly-Cys-Phe- Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-OH(Disulfide bridge:Cys23-Cys39) |
Peptide Structure | 
|
Molecular Formula | C176H290N56O51S3 |
Molecular Weight | 4102.77 |
订购联系方式：
上海鸿肽生物科技有限公司
手机： +86-18018095145 （同微信号）
QQ: 3259098395
邮箱：sales1@hongtide.com
关键字： 1480724-61-5;vosoritide;伏索利肽;Vosoritide acetate;多肽;
上海鸿肽生物科技有限公司（简称：鸿肽生物）是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖：定制多肽、目录多肽、氨基酸衍生物、小分子化合物；公司自成立以来，秉持“用质量作船， 以服务为帆，为科研服务”的企业理念，为国内外众多科研工作者提供了优质的服务及产品。