Product Name:Tat-beclin 1
CAS No.:1423821-88-8
Synonyms:自噬蛋白区域衍生肽
Catalog No.:218P069
Brand:HongTide(上海鸿肽生物)
Description:Tat-beclin 1 是一种自噬蛋白区域 (beclin 1) 衍生的多肽,是自噬 (autophagy) 的有效诱导剂,序列中含有31个氨基酸,并且具有穿膜的生理学功能,并与自噬的负调控因子 GAPR-1 (GLIPR2) 相互作用。Tat-beclin 1 减少了体外聚谷氨酰胺扩增蛋白聚集物的积累和多种病原体(包括 HIV-1) 的复制,并降低了感染基孔肯雅病 (CHIKV) 或西尼罗河病毒 (WNV) 的小鼠的死亡率。
Tat-beclin 1 is a peptide derived from the autophagic protein region (beclin 1), which is an effective inducer of autophagy. The sequence contains 31 amino acids, and has a physiological function of penetrating the membrane. It interacts with the negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 reduces the accumulation of polyglutamine amplified protein aggregates and the replication of various pathogens, including HIV-1, in vitro, and reduces the mortality of mice infected with Chikungunya disease (CHIKV) or West Nile virus (WNV).
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | YGRKKRRQRRRGGTNVFNATFEIWHDGEFGT |
Sequence(3-letter code) | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr-OH |
Peptide Structure | 
|
Molecular Formula | C164H251N57O45 |
Molecular Weight | 3741.16 |
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上海鸿肽生物科技有限公司
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关键字: 1423821-88-8;Tat-beclin 1;自噬蛋白区域衍生肽;多肽;多肽合成;
上海鸿肽生物科技有限公司(简称:鸿肽生物)是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖:定制多肽、目录多肽、氨基酸衍生物、小分子化合物;公司自成立以来,秉持“用质量作船, 以服务为帆,为科研服务”的企业理念,为国内外众多科研工作者提供了优质的服务及产品。