别名
1-[3,5-双(三氟甲基)苯基)-3-{(R)(6-甲氧基-4-喹啉基)-[(2R,4S,5R)-5-乙烯基-1-氮杂-二环[2.2.2]辛-2-基]甲基}硫脲,epi-N-奎宁基-N′-双(3,5-三氟甲基)苯硫脲
一般描述
The product is a cinchona-alkaloid-derived, bifunctional catalyst containing a thiourea group at position 9.
应用
采用双官能金鸡纳有机催化剂,进行硝基甲烷的高度对映选择性共轭加成反应,生成查耳酮 N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxy-9-cinchonanyl]thiourea may be used to catalyze the formation of optically active Mannich adducts from stable N-carbamate amido sulfones via enantioselective Mannich reaction.
特点和优势
N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(9R)-6′-methoxy-9-cinchonanyl]thiourea as an organocatalyst has the following advantages over transition-metal catalysis:Lower toxicityLower costsAir and moisture stability for simple reaction setup
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
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