Product Name:NGR Peptide
CAS No.:651328-78-8
Synonyms:Cell‐penetrating Peptides;细胞穿膜肽NGR Peptide
Catalog No.:218P120
Brand:HongTide(上海鸿肽生物)
Description:NGR peptide 是含有天冬酰胺-甘氨酸-精氨酸(NGR)序列的细胞穿膜肽,NGR peptide可靶向肿瘤新生血管上皮细胞特异过量表达的CD13受体。
NGR peptide可以选择性地与APN / CD13结合,可以免疫捕获或在细胞表面表达,同时NGR peptide具有的肿瘤选择性。 与NGR peptide偶联的抗癌药物阿霉素(DOX)表现出比游离药物本身更高的抗肿瘤作用,甚至更低的毒性。体内NGR peptide显像不仅可以提供有关NGR靶向过程的更多信息,包括生物分布和药代动力学,还可以揭示与肿瘤进展和恶性肿瘤有关的血管生成活性。
NGR peptide is a cell penetrating peptide containing the asparagine glycine arginine (NGR) sequence, which can target CD13 receptors specifically overexpressed in tumor neovascular epithelial cells.
NGR peptide can selectively bind to APN/CD13 and can be immunocaptured or expressed on the cell surface, while NGR peptide has the greatest tumor selectivity. The anticancer drug doxorubicin (DOX) coupled with NGR peptide exhibits higher anti-tumor effects and even lower toxicity than the free drug itself. In vivo NGR peptide imaging can not only provide more information about NGR targeting processes, including biological distribution and pharmacokinetics, but also reveal angiogenesis activity related to tumor progression and malignancy.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | CNGRCG |
Sequence(3-letter code) | H-Cys-Asn-Gly-Arg-Cys-Gly-OH |
Peptide Structure | ![NGR Peptide 651328-78-8.png NGR Peptide 651328-78-8.png](/SupplyImg/2023-04-09/6381663540422354223300415.jpg)
|
Molecular Formula | C20H36N10O8S2 |
Molecular Weight | 608.76 |
订购联系方式:
上海鸿肽生物科技有限公司
手机: +86-18018095145 (同微信号)
QQ: 3259098395
邮箱:sales1@hongtide.com
关键字: 651328-78-8;NGR Peptide;细胞穿膜肽 NGR Peptide;多肽;多肽合成;
上海鸿肽生物科技有限公司(简称:鸿肽生物)是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖:定制多肽、目录多肽、氨基酸衍生物、小分子化合物;公司自成立以来,秉持“用质量作船, 以服务为帆,为科研服务”的企业理念,为国内外众多科研工作者提供了优质的服务及产品。