| 中文名 | 卡那霉素B
|
| 英文名 | bekanamycin
|
| 别名 | 卡那霉素B
卡那霉素 B
卡那霉素杂质B
卡那霉素杂质3
妥布霉素 EPA
妥布霉素EP杂质A
(2R,3S,4R,5R,6R)-5-氨基-2-(氨基甲基)-6-(((1R,2S,3S,4R,6S)-4,6-二氨基-3-(((2S ,3R,4S,5S,6R)-4-氨基-3,5-二羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-2-羟基环己基)氧基)四氢-2H-吡喃- 3,4-二醇
|
| 英文别名 | kdm
NK 1006
nebramycinv
Bekanamycin
bekanamycin
Kanamycin B
kanendomycin
nebramycinfactor5
Nebramycin factor 5
d-streptamine,o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-4)-o-(2,6-diamino-2,
4,6-diamino-3-[(3-amino-3-deoxyhexopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxyhexopyranoside
(2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4-diol
|
| CAS | 4696-76-8
|
| EINECS | 225-170-5 |
| 化学式 | C18H37N5O10
|
| 分子量 | 483.51 |
| InChI | InChI=1/C18H37N5O10/c19-2-6-11(26)12(27)9(23)17(30-6)32-15-4(20)1-5(21)16(14(15)29)33-18-13(28)8(22)10(25)7(3-24)31-18/h4-18,24-29H,1-3,19-23H2 |
| 密度 | 1.3771 (rough estimate) |
| 熔点 | 178-182° (dec) |
| 沸点 | 580.49°C (rough estimate) |
| 比旋光度 | D18 +130° (c = 0.5 in water); D21 +114° (c = 0.98 in water) |
| 闪点 | 442.3°C |
| 蒸汽压 | 3.43E-30mmHg at 25°C |
| 溶解度 | Aqueous Acid (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Sparingl |
| 折射率 | 1.7600 (estimate) |
| 酸度系数 | 13.07±0.70(Predicted) |
| 存储条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 稳定性 | Hygroscopic |
| 外观 | Solid |
| 颜色 | Crystals |
| 产品用途 | 为抗生素类药，也是生产硫酸地贝卡星和硫酸阿贝卡星的中间体 |
| 体外研究 | Bekanamycin (Kanamycin B) is a precursor for semisynthetic antibiotics such as Arbekacin and Dibekacin and is generally extracted from the broth of S. kanamyceticus . Bekanamycin (Kanamycin B) in a concentration-dependent fashion reduces reversibly the quantal content of the end-plate potentials while it has no observable effect on the configuration of the extracellularly recorded presynaptic action potential. The reduction in evoked transmitter release produced by Bekanamycin could be antagonized either by increasing the external calcium concentration or by drugs like the aminopyridines which are to greatly enhance transmitter release from motor nerve terminals. Bekanamycin exerts potent inhibitory effects on transmitter release probably by interfering with the influx of calcium that occurs during depolarization of motor nerve terminals. |
| 上游原料 | 营养肉汤(NB) |
| 下游产品 | 阿贝卡星 |