Product Name:TRV-120027
CAS No.:1234510-46-3
Synonyms:血管紧张素II受体1型激动剂多肽TRV-120027
Catalog No.:218P125
Brand:HongTide(上海鸿肽生物)
Description:TRV-120027是血管紧张素 II 受体 1 型 (AT1R) 的β-arrestin-1激动剂多肽,多肽序列中含有8个氨基酸,可通过阳离子通道亚家族 C3 (TRPC3) 偶联诱导急性儿茶酚胺分泌,促进质膜上 AT1R-β-arrestin-1-TRPC3-PLCγ 形成大分子复合物。抑制血管紧张素 II 介导的血管收缩并增加心肌细胞的收缩力。有潜力用于急性失代偿性心力衰竭 (ADHF) 的研究。
TRV-120027 is a type of angiotensin II receptor 1 (AT1R) β- Arrestin-1 agonist peptide, containing 8 amino acids in the peptide sequence, can induce acute catecholamine secretion through the coupling of cationic channel subfamily C3 (TRPC3), promoting AT1R on the plasma membrane- β- arrestin-1-TRPC3-PLC γ Forming macromolecular complexes. Inhibiting angiotensin II mediated vasoconstriction and increasing the contractility of myocardial cells. There is potential for research on acute decompensated heart failure (ADHF).
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | Sar-RVYIHP-d-A |
Sequence(3-letter code) | H-Sar-Arg-Val-Tyr-Ile-His-Pro-D-Ala-OH |
Peptide Structure | ![TRV-120027 1234510-46-3.png TRV-120027 1234510-46-3.png](/SupplyImg/2023-04-10/6381675334978597694551363.jpg)
|
Molecular Formula | C43H67N13O10 |
Molecular Weight | 926.07 |
订购联系方式:
上海鸿肽生物科技有限公司
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QQ: 3259098395
邮箱:sales1@hongtide.com
关键字: 234510-46-3;TRV-120027;血管紧张素II受体1型激动剂多肽;多肽;多肽合成;
上海鸿肽生物科技有限公司(简称:鸿肽生物)是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖:定制多肽、目录多肽、氨基酸衍生物、小分子化合物;公司自成立以来,秉持“用质量作船, 以服务为帆,为科研服务”的企业理念,为国内外众多科研工作者提供了优质的服务及产品。