Product Name：Endothelin-1, human
CAS No.：117399-94-7
Synonyms：Endothelin 1 (swine, human)；内皮素-1
Catalog No.：137P15
Brand：HongTide（上海鸿肽生物）
Description：Endothelin 1 (swine, human) 是具有人和猪内皮素1序列的合成肽，是有效的内源性血管收缩剂多肽，序列中含有15个氨基酸，并且包含两对二硫键，由于其特殊结构，化学合成方法难度很大。Endothelin 1 通过两种类型受体ETA和ETB发挥作用。Endothelin-1 (ET-1)是一种有效的内源性血管收缩剂，主要由内皮细胞分泌。Endothelin-1通过两种类型的受体起作用：ETA 和 ETB。 除了血管收缩作用外，Endothelin-1还会导致血管细胞纤维化并刺激活性氧的产生。据称Endothelin-1可诱导促炎机制，增加超氧阴离子的产生和细胞因子的分泌。
Endothelin 1 (swine, human) is a synthetic peptide with human and porcine endothelin 1 sequences. It is an effective endogenous vasoconstrictor peptide, containing 15 amino acids and two pairs of disulfide bonds. Due to its unique structure, chemical synthesis methods are very difficult. Endothelin 1 works through two types of receptors, ETA and ETB. Endothelin-1 (ET-1) is an effective endogenous vasoconstrictor mainly secreted by endothelial cells. Endothelin-1 works through two types of receptors: ETA and ETB. In addition to vasoconstriction, Endothelin-1 can also cause vascular cell fibrosis and stimulate the production of reactive oxygen species. It is said that Endothelin-1 can induce pro-inflammatory mechanisms, increase the production of superoxide anions and the secretion of cytokines.
Purity (HPLC) ≥95.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | CSCSSLMDKECVYFCHLDIIW(Disulfide bridge：Cys1-Cys15;Cys3-Cys11) |
Sequence(3-letter code) | H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH(Disulfide bridge:Cys1-Cys15,Cys3-Cys11) |
Peptide Structure | 
|
Molecular Formula | C109H159N25O32S5 |
Molecular Weight | 2491.95 |
订购联系方式：
上海鸿肽生物科技有限公司
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QQ: 3259098395
邮箱：sales1@hongtide.com
关键字： 117399-94-7;Endothelin-1, human;内皮素-1;多肽;多肽合成;
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