Host:Rabbit
Target Protein:THRB1
IR:Immunogen Range:201-300/461
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:7068
Swiss Prot:P10828
Source:KLH conjugated synthetic peptide derived from human Thyroid Hormone Receptor beta:201-300/461
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptor b2 (TRb2) is a high affinity receptor for triiodothyronine which belongs to the nuclear hormone receptor family and the NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain. Defects in the receptor result in generalized thyroid hormone resistance (GTHR). GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1ug/Test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Cow
Rabbit
Sheep
.
![搜狗截图23年04月20日1717_10.png 搜狗截图23年04月20日1717_10.png](/SupplyImg/2023-04-20/6381760784099528437226796.jpg)
本产品仅供科研使用。不能用于人和动物治疗等其它临床诊断使用!
关键字: THRB1;THβ2;THβ1;THR1;THR 1;
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