Host:Rabbit
Target Protein:Bub3
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:9184
Swiss Prot:O43684
Source:Recombinant human Bub3:
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)IP(1:20-50)IHC-P(1:50-200)IHC-F(1:50-200)ICC(1:50-200)IF(1:50-200)
Cross Reactive Species:HumanMouseRat
本产品仅供科研使用。不能用于人和动物治疗等其它临床诊断使用!
上海沪震实业有限公司
联系商家时请提及chemicalbook,有助于交易顺利完成!