Product Name:Hepcidin-25
CAS No.:1356390-47-0
Synonyms:Hepcidin-25 (human) trifluoroacetate salt;LEAP-1;肝杀菌蛋白;铁调素
Catalog No.:159P05
Brand:HongTide(上海鸿肽生物)
Description:Hepcidin-25也称为LEAP-1(肝脏表达的抗菌肽)在人血液超滤液和尿液中独立发现。该肽主要在肝脏中表达,属于新的脊椎动物小抗菌肽家族,含有8个半胱氨酸残基,显示出显着的抗菌和抗真菌活性。 进一步的研究表明,hepicidin 是人类主要的铁调节激素。 Hepcidin-25通过与铁转运蛋白结合,诱导其内化和降解,从而阻断细胞铁流出。
Hepcidin-25, also known as LEAP-1 (liver expressed antimicrobial peptide), is independently found in human blood ultrafiltration and urine. This peptide is mainly expressed in the liver and belongs to a new family of small antimicrobial peptides in vertebrates. It contains 8 cysteine residues and exhibits significant antibacterial and antifungal activities. Further research suggests that hepicidin is the main iron regulatory hormone in humans.Hepcidin-25 induces internalization and degradation by binding to iron transporters, thereby blocking cellular iron efflux.
Purity (HPLC) ≥75.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | DTHFPICIFCCGCCHRSKCGMCCKT(Disulfide bonds between Cys7 and Cys23;Cys10 and Cys13;Cys11 and Cys19;Cys14 and Cys22) |
Sequence(3-letter code) | H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH(Disulfide bonds between Cys7 and Cys23;Cys10 and Cys13;Cys11 and Cys19;Cys14 and Cys22) |
Peptide Structure | ![Hepcidin-25 1356390-47-0.png Hepcidin-25 1356390-47-0.png](/SupplyImg/2023-04-25/6381801849064512042888666.jpg)
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Molecular Formula | C113H170N34O31S9 |
Molecular Weight | 2789.35 |
订购联系方式:
上海鸿肽生物科技有限公司
手机: +86-18018095145 (同微信号)
QQ: 3259098395
邮箱:sales1@hongtide.com
关键字: Hepcidin-25;1356390-47-0;肝杀菌蛋白;铁调素;Hepcidin-25 (human) ;
上海鸿肽生物科技有限公司(简称:鸿肽生物)是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖:定制多肽、目录多肽、氨基酸衍生物、小分子化合物;公司自成立以来,秉持“用质量作船, 以服务为帆,为科研服务”的企业理念,为国内外众多科研工作者提供了优质的服务及产品。