Host:Rabbit
Target Protein:CDKN1B/p27 KIP 1
IR:Immunogen Range:101-198/198
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:1027
Swiss Prot:P46527
Source:KLH conjugated synthetic peptide derived from human P27 kip1:101-198/198
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. p27 Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27 Kip 1; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IP(1:20-100)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1μg/Test )
IF(1:200-800)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Sheep
本产品仅供科研使用。不能用于人和动物治疗等其它临床诊断使用！
关键字： CDKN1B;p27 KIP 1;AA408329;AI843786;Cdki1b;
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