Host:Rabbit
Target Protein:PDPK1
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:5170
Swiss Prot:O15530
Source:KLH conjugated synthetic peptide derived from human PDK1:
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases.
PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
IP(1:20-100)
IHC-P(1:50-200)
Flow-Cyt(1:50)
ICC(1:50)
Cross Reactive Species:Human
Mouse
Rat
本产品仅供科研使用。不能用于人和动物治疗等其它临床诊断使用！
关键字： PDK1;PkB like 1;PDPK1;hPDK 1;hPDK 1;
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