Host:Rabbit
Target Protein:CLOCK
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:9575
Swiss Prot:O15516
Source:KLH conjugated synthetic peptide derived from human CLOCK :
Purification:affinity purified by Protein A
Storage:1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-1000)
IHC-P(1:50-200)
Flow-Cyt(1:50)
ICC(1:50)
IF(1:50-200)
Cross Reactive Species:Human
Mouse
Rat
.
本产品仅供科研使用。不能用于人和动物治疗等其它临床诊断使用！
关键字： hCLOCK;BHLHE8;KIAA0334;CLOCK_HUMAN;CLOCK;
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