Product Name:HXR9
CAS No.:917953-08-3
Synonyms:细胞渗透性多肽
Catalog No.:218P200
Brand:HongTide(上海鸿肽生物)
Description:HXR9是一种细胞渗透性多肽,序列中含有18个氨基酸,其中包含9个Arg,是 HOX/PBX 相互作用 (HOX/PBX interaction) 的竞争性拮抗剂。HXR9 拮抗 HOX 与第二转录因子 (PBX) 之间的相互作用,PBX 与旁系同源基因组 1 至 8 中的 HOX 蛋白结合。HXR9 选择性地减少细胞增殖并促进 HOXA/PBX3 基因高水平表达的细胞,例如 MLL 重排的白血病细胞中的细胞凋亡 (apoptosis)。
HXR9 is a cell permeable peptide with 18 amino acids in its sequence, including 9 Args. It is a competitive antagonist to the HOX/PBX interaction. HXR9 antagonizes the interaction between HOX and the second transcription factor (PBX), which binds to HOX proteins in homologous genomes 1 to 8. HXR9 selectively reduces cell proliferation and promotes high-level expression of HOXA/PBX3 genes in cells, such as apoptosis in MLL rearranged leukemia cells.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | WYPWMKKHHRRRRRRRRR |
Sequence(3-letter code) | H-Trp-Tyr-Pro-Trp-Met-Lys-Lys-His-His-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-OH |
Peptide Structure | ![HXR9 917953-08-3.png HXR9 917953-08-3.png](/SupplyImg/2023-05-03/6381871780684325265062925.jpg)
|
Molecular Formula | C119H193N53O20S1 |
Molecular Weight | 2718.26 |
订购联系方式:
上海鸿肽生物科技有限公司
手机: +86-18018095145 (同微信号)
QQ: 3259098395
邮箱:sales1@hongtide.com
关键字: 917953-08-3;HXR9 ;细胞渗透性多肽;多塔;多肽合成;
上海鸿肽生物科技有限公司(简称:鸿肽生物)是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖:定制多肽、目录多肽、氨基酸衍生物、小分子化合物;公司自成立以来,秉持“用质量作船, 以服务为帆,为科研服务”的企业理念,为国内外众多科研工作者提供了优质的服务及产品。