Product Name：B7-33
CAS No.：N/A
Synonyms：(B7-33)H2；B7-33 relaxin；类H2 relaxin多肽
Catalog No.：218P235
Brand：HongTide（上海鸿肽生物）
Description：B7-33是一种人工设计的类似于H2 relaxin的多肽，使一条由27个氨基酸组成的多肽。B7-33通过优先与磷酸化丝裂原活化蛋白激酶胞外信号调节激酶，从而激活松弛素肽受体1的信号传导。在动物模型实验中可以得出B7-33可减轻心肌细胞死亡和内质网应激，保护心脏功能，对小鼠急性心肌损伤具有保护作用。同时B7-33在体外成纤维细胞、大鼠和小鼠体内纤维化模型中被证明能特异性结合松弛素受体RXFP1，并优先激活与抗纤维化作用相关的通路，而无副作用。
B7-33 is an artificially designed peptide similar to H2 relaxin, consisting of 27 amino acids. B7-33 activates the extracellular signal regulated kinase of protein kinase by preferentially phosphorylating mitogen, thereby activating the signal transduction of relaxin peptide receptor 1. In the animal model experiment, it can be concluded that B7-33 can reduce myocardial cell death and endoplasmic reticulum stress, protect the heart function, and have a protective effect on acute myocardial injury in mice. At the same time, B7-33 has been shown to specifically bind to the relaxin receptor RXFP1 in vitro fibroblasts, rat and mouse models of fibrosis, and preferentially activate pathways related to anti fibrosis effects without side effects.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | VIKLSGRELVRAQIAISGMSTWSKRSL |
Sequence(3-letter code) | H-Val-Ile-Lys-Leu-Ser-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Ser-Gly-Met-Ser-Thr-Trp-Ser-Lys-Arg-Ser-Leu-OH |
Peptide Structure | 
|
Molecular Formula | C131H228N40O37S |
Molecular Weight | 2987.75 |
订购联系方式：
上海鸿肽生物科技有限公司
手机： +86-18018095145 （同微信号）
QQ: 3259098395
邮箱：sales1@hongtide.com
关键字： B7-33;(B7-33)H2;B7-33 relaxin;类H2 relaxin多肽;多肽;
上海鸿肽生物科技有限公司（简称：鸿肽生物）是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖：定制多肽、目录多肽、氨基酸衍生物、小分子化合物；公司自成立以来，秉持“用质量作船， 以服务为帆，为科研服务”的企业理念，为国内外众多科研工作者提供了优质的服务及产品。