Host:Rabbit
Target Protein:Smad2
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:4087
Swiss Prot:Q15796
Source:Recombinant human Smad2 protein, around N-terminal 1-200aa:
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:SMAD2 or Mothers against decapentaplegic homolog 2 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decepentaplegic". It belongs to the SMAD family of proteins, which belong to the TGF-Beta superfamily of modulators. Like many other TGF-Beta family members SMAD2 is involved in cell signalling. SMAD2 modulates signals of activin and TGF-Beta's. It interacts with SMAD anchor for receptor activation (SARA). The binding of ligands causes the phosphorylation of the SMAD2 protein and the dissociation from SARA and the association with SMAD4. It is subsequently transferred to the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD2 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. This antibody is cross reactive with Smad3.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-1000)IHC-P(1:50-200)IHC-F(1:50-200)Flow-Cyt(2ug/Test)ICC(1:100)IF(1:50-200)
Cross Reactive Species:HumanMouseRat
本产品仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
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