Host:Rabbit
Target Protein:HDAC9
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:9734
Swiss Prot:Q9UKV0
Source:KLH conjugated synthetic peptide derived from human HDAC9:
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:HDAC9 (Histone Deacetylase 9) catalyses the deacetylation of lysine residues on the core histones (H2A, H2B, H3 and H4). It belongs to the Class IIa HDAC family, which are key regulators of several developmental and differentiation processes such as cardiac growth. HDAC9 represses MEF2 (myocyte enhancer factor 2)-dependent transcription, playing an important role in cardiac hypertrophy.The HDAC9 isoform MITR/HDRP lacks active site residues and is therefore catalytically inactive. It represses MEF2-dependent transcription by interacting with HDAC1 and/or HDAC3. MITR/HDRP is thought to play a role in skeletal myogenesis and in heart development. It also protects neurons from apoptosis by inhibiting c-Jun phosphorylation by MAPK10 and by repressing c-Jun transcription through recruitment of HDAC1 to the c-Jun promoter.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)IHC-P(1:50-200)ICC(1:50-200)
Cross Reactive Species:Human.
本产品仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
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