Host:Rabbit
Target Protein:MDR1
IR:Immunogen Range:21-100/1272
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:5243
Swiss Prot:P21447
Source:KLH conjugated synthetic peptide derived from human MDR1:21-100/1272
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1μg/Test)
ICC(1:100)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
![搜狗截图23年06月19日0954_14.png 搜狗截图23年06月19日0954_14.png](/SupplyImg/2023-06-19/6382276529494279134218091.jpg)
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: MDR1;ABCB1;gp170;P gp; p-GP;MDR1_HUMAN;PGY1;CLCS;
上海沪震实业有限公司是一家集研发、生产和销售于一体的生命科学实验室产品生物科技企业。主营产品:试剂盒,ELISA试剂盒,抗体,重组蛋白,血清,胎牛血清,细胞,原代细胞 细胞培养试剂,常用生化试剂。