Host:Rabbit
Target Protein:Axin 2
IR:Immunogen Range:331-430/843
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:8313
Swiss Prot:Q9Y2T1
Source:KLH conjugated synthetic peptide derived from human Axin 2 corresponding:331-430/843
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Involvement in disease:Defects in AXIN2 are involved in colorectal cancer (CRC). They appear to be specifically associated with defective mismatch repair.
Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS). Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Horse
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: Axil;Axin 2;Axin2;Axin-2;AXIN2_HUMAN;Conductin;Axis inhibition prot;Axin-like protein;
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