Rabbit Anti-Dnmt3b Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Dnmt3b
IR:Immunogen Range:1-80/853
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:1789
Swiss Prot:Q9UBC3
Source:KLH conjugated synthetic peptide derived from human Dnmt3 Beta:1-80/853
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently, it has been shown that naturally occurring mutations of Dnmt3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
![image.png image.png](/SupplyImg/2023-07-11/6382467179897983291353549.jpg)
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: Dnmt3b;Cytosine 5methyltran;DNA;DNA (cytosine 5) met;DNA methyltransferas;Dnmt3b;Dnmt3 Beta;DNM3B_HUMAN;
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