Rabbit Anti-NOX2 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:NOX2
IR:Immunogen Range:501-570/570
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:1536
Swiss Prot:P04839
Source:KLH conjugated synthetic peptide derived from human NOX2:501-570/570
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:NOX2/gp91phox is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
Rabbit
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： NOX2;AMCBX2;CGD;CGD91-phox;CY24B_HUMAN;CYBB;Cytochrome b 245,;beta polypeptide;
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