Rabbit Anti-LC3 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:LC3
IR:Immunogen Range:31-121/121
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:84557
Swiss Prot:Q9H492
Source:KLH conjugated synthetic peptide derived from human LC3:31-121/121
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(1μg/Test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
Sheep
Goat
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： LC3;Autophagy related pr;Autophagy related pr; MAP1A/1B light chai;MAP1A/1BLC3;AP1A/MAP1B LC3 A; MAP1A/MAP1B LC3 B;MLP3A_HUMAN;
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