Rabbit Anti-factor VIII Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:factor VIII
IR:Immunogen Range:401-500/2258
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:2157
Swiss Prot:Q7TN96
Source:KLH conjugated synthetic peptide derived from rat factor VIII:401-500/2258
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Rabbit
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： factor VIII;coagulation factor V;Dxs1253e;F8; F8 protein;F8c;FVIII;FA8_HUMAN;
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