Rabbit Anti-IL-4R Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:IL-4R
IR:Immunogen Range:201-300/825
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3566
Swiss Prot:P24394
Source:KLH conjugated synthetic peptide derived from human IL-4R:201-300/825
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008].
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Rat
Pig
Horse
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: IL-4R;CD124;IL 4R alpha;IL-4 receptor subuni;IL-4-binding protein; IL-4R subunit alpha;Soluble IL-4R-alpha;IL-4-Rα;
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