Rabbit Anti-CD137 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:CD137
IR:Immunogen Range:81-180/255
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3604
Swiss Prot:Q07011
Source:KLH conjugated synthetic peptide derived from human CD137 :81-180/255
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:CD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumour necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
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本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： CD137;TNFRSF9;Tumor necrosis facto; 4-1BB;4 1BB ligand recept;CDw137;MGC2172;TNR9_HUMAN;
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