Rabbit Anti-PEDF Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:PEDF
IR:Immunogen Range:201-300/418
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:5176
Swiss Prot:P97298
Source:KLH conjugated synthetic peptide derived from human PEDF:201-300/418
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Pigment epithelium derived factor, originally identified in conditioned medium of cultured human fetal retinal pigment epithelial (RPE) cells, is a neurotrophic protein that induces extensive neuronal differentiation in human Y79 retinoblastoma cells, a neoplastic counterpart of normal retinoblasts. It has been suggested that PEDF is synthesized by RPE cells and secreted into the retina interphotoreceptor matrix where it may influence development/differentiation of the neural retina. PEDF is a potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The PEDF gene is a member of the serpin gene family. Serpins are a group of serine protease inhibitors, some of which have also been reported to exhibit neurotrophic activity.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
本品仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： PEDF;pigment epithelium-d;Serpin-F1;Stromal cell-derived;SDF-3;Caspin;PIG35;PEDF_HUMAN;
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