Rabbit Anti-GRB2 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:GRB2
IR:Immunogen Range:101-217/217
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:2885
Swiss Prot:P62993
Source:KLH conjugated synthetic peptide derived from human GRB2:101-217/217
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Growth factor receptor bound protein 2 (GRB2), also known as Ash protein, is a 24 kDa protein that contains a central Src homology (SH2) domain flanked by two SH3 domains. GRB2 is believed to be a regulatory subunit of signaling molecules whose activity is modulated by receptor binding. GRB2 associates with activated (tyrosine phosphorylated) EGFR and PDGFR via its SH2 domain as well as IRS1, SHC, and LNK through SH2 and SH3 domains. The SH3 domain binds to SOS, a guanine nucleotide exchange factor for Ras proteins. Endocytosis of activated EGFR requires the interaction of GRB2 with the GTP binding protein dynamin, a factor essential to the formation of endocytotic vesicle. It is ubiquitously expressed and several isoforms are produced by alternative splicing. On SDS PAGE, GRB2 has an apparent molecular weight of 28 kDa.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
![image.png image.png](/SupplyImg/2023-07-20/6382547040584085575779457.jpg)
仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: GRB2;GRB2 adapter protein;Grb3 3;ASH;EGFRBP GRB2;OTTHUMP00000166096;OTTHUMP00000166097;OTTHUMP00000166098;
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