Rabbit Anti-PD-L1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:PD-L1
IR:Immunogen Range:
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:29126
Swiss Prot:Q9NZQ7
Source:KLH conjugated synthetic peptide derived from human B7-H1/PD-L1/CD274:
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
Cross Reactive Species:Human
Mouse
Rat
Pig
Cow
Horse
Rabbit
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： PD-L1;Programmed cell deat;CD274;B7 H1;B7 homolog 1;CD274 antigen;MGC142296;PD1L1_HUMAN;
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