Rabbit Anti-Fbx32 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Fbx32
IR:Immunogen Range:31-130/355
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:114907
Swiss Prot:Q969P5
Source:KLH conjugated synthetic peptide derived from human MAFbx:31-130/355
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Fbx32 is an E3 ubiquitin ligase that initiates ATP dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. It is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. It is also thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. Fbx32 interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(0.2ug/test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
Rabbit
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： Fbx32;4833442G10Rik;AI430017;Atrogin 1;ATROGIN1;MGC108443;MGC137646;FBX32_HUMAN;
上海沪震实业有限公司是一家集研发、生产和销售于一体的生命科学实验室产品生物科技企业。主营产品：试剂盒，ELISA试剂盒，抗体，重组蛋白，血清，胎牛血清，细胞，原代细胞 细胞培养试剂，常用生化试剂。