Rabbit Anti-Phospho-MDM2 (Ser186) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Phospho-MDM2 (Ser186)
IR:Immunogen Range:HK(p-S)D-NH2
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:4193
Swiss Prot:Q00987
Source:KLH conjugated Synthesised phosphopeptide derived from human MDM2 around the phosphorylation site of Ser186:HK(p-S)D-NH2
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Inhibits TP53/p53- and TP73/p73-mediated cell cyclearrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis. Binds p53, p73, ARF(P14), ribosomal protein L5 and specifically to RNA. Can interact also with retinoblastoma protein(RB), E1A-associated protein EP300 and the E2F1 transcription factor. Forms a ternary complex with TP53/p53 and WWOX. Interacts with CDKN2AIP, MTBP, TRBG1 and USP7. Isoform Mdm2-F does not interact with TP53/p53. Interacts with PYHIN1. Interacts with, and ubiquitinates HIV-1 Tat. Belongs to the MDM2/MDM4 family.
Sheep
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100)
IF(1:100-500)
Cross Reactive Species:Human
Chicken
Dog
Pig
Cow
Horse
Rabbit
Guinea Pig
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： Phospho-MDM2 (Ser186;MDM2 (phospho S186);p-MDM2 (phospho S186;MDM2(phospho S186);HDM2;Mdm2;MDM2BP;MDM2_HUMAN;
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