Rabbit Anti-phospho-TSC1 (Ser505) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-TSC1 (Ser505)
IR:Immunogen Range:FD(p-S)PF
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:7248
Swiss Prot:Q92574
Source:KLH conjugated Synthesised phosphopeptide derived from human TSC1 around the phosphorylation site of Ser505:FD(p-S)PF
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
Rabbit
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： phospho-TSC1 (Ser505;TSC1(phospho S505) ;TSC1(phospho Ser505);LAM;Hamartin;Tuberous sclerosis 1;KIAA0243;TSC1_HUMAN;
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