Rabbit Anti-phospho-AMPK beta 1 + AMPK beta 2 (Ser182/Ser184) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:phospho-AMPK beta 1 + AMPK beta 2 (Ser182/Ser184)
IR:Immunogen Range:SS(p-S)PP
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:5564
Swiss Prot:Q9Y478
Source:KLH conjugated synthesised phosphopeptide derived from human AMPK beta 1 around the phosphorylation site of Ser182:SS(p-S)PP
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008].
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(2ug/Test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Cow
Horse
Rabbit
仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: phospho-AMPK beta 1 ; PRKAB1(phospho S182;PRKAB1(phospho-S182);Phospho-Stat3(pTyr70;p-AMPK beta 1(S182);MPK beta 2(phospho S;HAMPKb;AAKB1_HUMAN;
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