Rabbit Anti-5HT2C Receptor Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:5HT2C Receptor
IR:Immunogen Range:311-410/458
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3358
Swiss Prot:P28335
Source:KLH conjugated synthetic peptide derived from human 5HTR2C:311-410/458
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq, Jul 2008].
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Horse
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： 5HT2C Receptor;5 Hydroxytryptamine ;5-HT-1C;5-ht-1c receptor;5-HTR2C;5HTR2C;HTR2C;5HT2C_HUMAN;
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