Rabbit Anti-FOXO1 + FOXO3 + FOXO4 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:FOXO1 + FOXO3 + FOXO4
IR:Immunogen Range:201-300/655
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:2308
Swiss Prot:Q12778
Source:KLH conjugated synthetic peptide derived from human FOXO1/FOXO3/FOXO4:201-300/655
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined. FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia. FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Horse
Sheep
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： FOXO1 + FOXO3 + FOXO;FOXO1;FOXO3;FOXO4;FKHRL1;FKHRL1P2;FOXO4_HUMAN;FOXO3_HUMAN;
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