Rabbit Anti-UHRF1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:UHRF1
IR:Immunogen Range:701-793/793
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:29128
Swiss Prot:Q96T88
Source:KLH conjugated synthetic peptide derived from human UHRF1:701-793/793
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-F(1:100-500)
Flow-Cyt(1ug/test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Horse
Guinea Pig
![3.png 3.png](/SupplyImg/2023-07-25/6382589804703065742147513.jpg)
仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: UHRF1;E3 ubiquitin-protein;ICBP90;NP95;RNF106;TDRD22;hUHRF1;UHRF1_HUMAN;
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