Rabbit Anti-PA26 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:PA26
IR:Immunogen Range:401-492/492
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:27244
Swiss Prot:Q9Y6P5
Source:KLH conjugated synthetic peptide derived from human SESN1/PA26:401-492/492
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Cell cycle progression is subject to arrest at G1 and G2 checkpoints in response to DNA damage, presumably to allow time for DNA repair prior to entry into S and M phase, respectively. The p53 tumor suppressor is required for one such G1 checkpoint and functions to upregulate expression of GADD 45 and the mitotic inhibitory protein p21. GADD 45 stimulates DNA excision repair in vitro and inhibits entry of cells into S phase, and it apparently acts in concert with GADD 153 in inducing growth arrest. A related DNA-damage inducible gene, GADD 34 synergizes with GADD 45 or GADD 153 in suppressing cell growth. PEG-3 (progression elevated gene-3) shares significant homology with GADD 34 and is inducible by DNA damage. An additional GADD related gene, PA26, is a possible target of p53. Three isoforms of PA26 have been identified as PA26-T1, PA26-T2 and PA26-T3.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(3ug/Test)
IF(1:50-200)
Cross Reactive Species:Human
Mouse
Rat
Dog
Cow
Horse
Sheep
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： PA26;p53 regulated PA26 n;p53 regulated protei;Phospho-Stat3（pTyr70;p53-regulated protei;sesn1;Sestrin-1;SESN1_HUMAN;
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