Rabbit Anti-NCF1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:NCF1
IR:Immunogen Range:12-120/390
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:653361
Swiss Prot:P14598
Source:KLH conjugated synthetic peptide derived from human p47-phox:12-120/390
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47-phox and p67-phox. The cytosolic proteins p47-phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47-phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47-phox, suggesting that p47-phox may faciliate the transport of p67-phox to the membrane.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:50-200)
Cross Reactive Species:Human
Mouse
Rat
Dog
Pig
Cow
Rabbit
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： NCF1;NCF 47K;NCF-1;NCF-47K;Nox organizer 2;Neutrophil NADPH oxi;NOXO2;NCF1_HUMAN;
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