Rabbit Anti-HAAO Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:HAAO
IR:Immunogen Range:101-200/286
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:23498
Swiss Prot:P46952
Source:KLH conjugated synthetic peptide derived from human HAAO:101-200/286
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The 3-HAO family of proteins consists of intramolecular dioxygenases that contain non-heme ferrous iron. HAAO (3-hydroxyanthranilate 3,4-dioxygenase), also known as HAO or 3-HAO, is a 286 amino acid monomeric cytoplasmic protein that belongs to the 3-HAO family. Utilizing Fe2+ ions as a cofactor, HAAO participates in the formation of quinolinic acid (QUIN), and excitotoxin, by catalyzing the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde. HAAO may play a role in disorders that are associated with varying levels of QUIN expression, and is widely expressed in peripheral organs, including kidney and liver. Existing as two alternatively spliced isoforms, the gene encoding HAAO maps to human chromosome 2p21 and mouse chromosome 17 E4.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
Cross Reactive Species:Human
Mouse
Rat
Pig
Cow
Rabbit
Sheep
![image.png image.png](/SupplyImg/2023-07-26/6382596776403442417927293.jpg)
仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: HAAO;3 HAO;3 hydroxyanthranilat;3 hydroxyanthranilat; 3-HAO;3-hydroxyanthranilat; 3-hydroxyanthranila;3HAO_HUMAN;
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