Product Name:BK-1361(cyclo(RLsKDK))
CAS No.:1975145-82-4
Synonyms:抑制剂多肽BK-1361;BK1361;cyclo-RLsKDK)
Catalog No.:218P424
Brand:HongTide(上海鸿肽生物)
Description:BK-1361(cyclo(RLsKDK))是一种由6个氨基酸组成的环肽,其中含好一个D型氨基酸,其作为ADAM8的有效选择性抑制剂起作用,IC50为120nM;BK-1361(cyclo(RLsKDK))对ADAM 9,10,12没有显示出显着活性。BK-1361(cyclo(RLsKDK))在基于细胞的脱落测定中抑制CD23的脱落,IC50为182nM,减少胰腺癌细胞的迁移/侵袭,减少ERK1/2和MMP活化,引起细胞形态的变化;同时减少肿瘤负荷和植入的胰腺肿瘤细胞的转移,并提供Kras(G12D)驱动的临床症状和存活的改善指标PDAC的小鼠模型。
BK-1361 (cycli (RLsKDK)) is a cyclic peptide composed of six amino acids, which contains a D-type amino acid. It acts as an effective selective inhibitor of ADAM8, with an IC50 of 120 nM; BK-1361 (cycle (RLsKDK)) did not show significant activity against ADAM 9,10,12. BK-1361 (cycli (RLsKDK)) inhibits CD23 shedding in cell-based shedding assay, IC50 is 182 nM, reduces migration/invasion of pancreatic cancer cells, reduces ERK1/2 and MMP activation, and causes changes in cell morphology; A mouse model of PDAC that simultaneously reduces tumor burden and metastasis of implanted pancreatic tumor cells, and provides clinical symptom and survival improvement indicators driven by Kras (G12D).
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | cyclo(RL{d-S}KDK) |
Sequence(3-letter code) | cyclo(Arg-Leu-D-Ser-Lys-Asp-Lys) |
Peptide Structure | |
Molecular Formula | C31H57N11O9 |
Molecular Weight | 727.86 |
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上海鸿肽生物科技有限公司
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QQ: 3259098395
邮箱:sales1@hongtide.com
关键字: 1975145-82-4;BK-1361(cyclo(RLsKDK;抑制剂多肽BK-1361;cyclo-RLsKDK;多肽;
上海鸿肽生物科技有限公司(简称:鸿肽生物)是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖:定制多肽、目录多肽、氨基酸衍生物、小分子化合物;公司自成立以来,秉持“用质量作船, 以服务为帆,为科研服务”的企业理念,为国内外众多科研工作者提供了优质的服务及产品。