Rabbit Anti-Phospho-TAK1 (Thr184) Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Phospho-TAK1 (Thr184)
IR:Immunogen Range:IQ(p-T)HM
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:6885
Swiss Prot:O43318
Source:KLH conjugated Synthesised phosphopeptide derived from human TAK1 around the phosphorylation site of Thr184:IQ(p-T)HM
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:TAK1 (or MAP3K7) was shown to participate in regulation of transcription by transforming growth factor beta (TGF beta). TAK1 is stimulated in response to TGF beta and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF beta superfamily members. TAB1 and TAB2 are TAK1 binding proteins that may function as activators of the TAK1 (TGF b activated kinase 1) MAPKKK in TGF b signal transduction. TAB1 induced TAK1 activation promoted the dissociation of active forms of IKKa and IKK b from active TAK1, whereas the IKK mutants remained to interact with active TAK1. TNF a activated endogenous TAK1, and the kinase negative TAK1 acted as a dominant negative inhibitor against TNF a induced NFkB activation. TAK1 was suggested to act as a regulatory kinase of IKKs.
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Pig
Cow
Horse
Rabbit
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： Phospho-TAK1 (Thr184;TAK1 (phospho T184);p-TAK1 (phospho T184;MAP3K7; TGF-beta-activated ;TGF1a;Transforming growth ;M3K7_HUMAN;
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