Rabbit Anti-PDIA2 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:PDIA2
IR:Immunogen Range:431-525/525
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:64714
Swiss Prot:Q13087
Source:KLH conjugated synthetic peptide derived from human PDIA2/PDI:431-525/525
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:1000-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
![image.png image.png](/SupplyImg/2023-07-31/6382639055943956567081707.jpg)
仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: PDIA2;P4HB;Pancreatic protein d;PDA2;PDI;PDIA2;PDIR;PDIA2_HUMAN;
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