Rabbit Anti-EDA2R Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:EDA2R
IR:Immunogen Range:51-150/297
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:60401
Swiss Prot:Q9HAV5
Source:KLH conjugated synthetic peptide derived from human EDA2R/TNFRSF27:51-150/297
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The tumor necrosis factor receptor (TNFR) superfamily represents a growing family of type I transmembrane glycoproteins that are involved in various cellular functions, including proliferation, differentiation and programmed cell death (1–3). These proteins share homology for cysteine-rich repeats in the extracellular ligand binding domain and an intracellular death domain (1–3). Members of the TNFR superfamily transmit signals through protein-protein interactions, and these signals can lead to the activation of either the caspase and Jun kinase pathways, which promote cell death, or the NFkB pathway, which results in cell survival (1). The ectodermal dysplasia receptor (EDAR) promotes all three of these pathways and mediates ectodermal differentiation (4). EDAR is encoded by the downless gene and is mutated in ectodermal dysplasia syndromes, which are characterized by impaired hair, teeth and sweat gland development (5). Ectodysplasin A (EDA) is a type II membrane protein that is encoded by the Tabby gene and produces many splice variants, the longest of which, EDA-A1, serves as the ligand for EDAR (5–7). EDA-A2, which differs from EDA-A1 by the deletion of two amino acids, binds only the X-linked ectodysplasin-A2 receptor (XEDAR) (7). Both EDAR and XEDAR exhibit homology with TROY (8).
Size:50ul
Concentration:1mg/ml
Applications:ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
![image.png image.png](/SupplyImg/2023-08-01/6382648062388916611712300.jpg)
仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: EDA2R;Ectodysplasin A2 rec;EDA-A2 receptor;EDA2R;TNFRSF27; X-linked ectodyspla;XEDAR;TNR27_HUMAN;
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